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What exactly does ALS stand for?   No clue? Ok GK Time. Amyotrophic lateral sclerosis (ALS) — Lou Gehrig’s disease in North America, and rarely Charcot disease—is aneurodegenerative disorder with various causes. The term motor neuron disease (MND) is often used interchangeably with ALS, while others use it to refer to a group of similar conditions that include ALS. ALS is characterized by …